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Post-Polio Syndrome Diagnosis
In order to make a post-polio syndrome diagnosis, doctors will ask for a medical history, perform a physical exam, and recommend certain tests. A number of other medical conditions (such as depression and chronic fatigue syndrome) share similar symptoms with post-polio syndrome, so doctors will consider these before making a diagnosis.
In order to make a post-polio syndrome diagnosis, the doctor will ask the patient a number of questions about:
- Symptoms
- Past medical history, including a history of poliovirus infection
- Current medical conditions
- Family history of medical conditions
- Current medications.
In addition, the doctor will perform a physical exam to look for signs and symptoms of post-polio syndrome. The doctor will also recommend certain tests.
In order to make a make a post-polio syndrome diagnosis and exclude other similar conditions, the doctor may recommend certain tests. These tests can help diagnose post-polio syndrome (or another medical condition), but they do not identify survivors at greatest risk for new progression of muscle weakness. Tests include:
- Magnetic resonance imaging (MRI)
- Computed tomography (CT)
- Neuroimaging tests
- Electromyography (EMG).
Less commonly, doctors may recommend a muscle biopsy or a spinal fluid analysis.
A number of other medical conditions share some similar symptoms with post-polio syndrome. Before making a post-polio syndrome diagnosis, the doctor will consider these diseases and conditions, which include:
- Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease
- Depression
- Chronic fatigue syndrome.
Written by/reviewed by: Arthur Schoenstadt, MD
Last reviewed by: Arthur Schoenstadt, MD



